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Comment
. 2015 Nov;88(5):944-6.
doi: 10.1038/ki.2015.267.

Uromodulin, kidney function, cardiovascular disease, and mortality

Olivier Devuyst  1 , Murielle Bochud  2
Affiliations
Free article
Comment

Uromodulin, kidney function, cardiovascular disease, and mortality

Olivier Devuyst et al. Kidney Int. 2015 Nov.
Free article

Abstract

Uromodulin (Tamm-Horsfall protein) is exclusively produced by the kidney and is the most abundant protein excreted in normal urine. The level of uromodulin in urine could represent a useful biomarker for renal tubular function. The study of Garimella et al. adds elements into the debate, by suggesting that, in elderly adults, low urinary uromodulin concentrations in spot urine identify people at risk of progressive kidney disease and mortality above and beyond established markers of kidney disease.

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References

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