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Review
. 2015 Nov;94(46):e1217.
doi: 10.1097/MD.0000000000001217.

Genetic Association Between CDKN1B rs2066827 Polymorphism and Susceptibility to Cancer

Yongchao Lu  1 , Kejian Gao, Miao Zhang, Aiyan Zhou, Xiaoming Zhou, Zhongan Guan, Xuewen Shi, Shujian Ge
Affiliations
Review

Genetic Association Between CDKN1B rs2066827 Polymorphism and Susceptibility to Cancer

Yongchao Lu et al. Medicine (Baltimore). 2015 Nov.

Abstract

Much attention has been directed to the association between cancer risk and rs2066827 polymorphism of the CDKN1B gene. However, the results are indefinitive and inconclusive. This study was devised to evaluate the hypothesis that rs2066827 polymorphism is associated with the risk of cancer.Computer-based databases (EMBASE, PubMed, and CNKI) were used to seek all case-control studies evaluating rs2066827 polymorphism and susceptibility to cancer. The genetic risk was assessed by calculating pooled odds ratio (OR) with its corresponding 95% confidence interval (CI). Fixed-effects pooled ORs were calculated by the Mantel-Haenszel method (Ph > 0.05), and random-effects pooled ORs were estimated by the DerSimonian-Laird method (Ph < 0.05).Data on rs2066827 polymorphism and cancer risk were available for 9038 cancer cases and 11,596 controls participating in 17 studies. Carriage of a TG genotype was associated with a minor but significant decrease in the risk of cancer (pooled OR 0.92, 95% CI: 0.86-0.99; model, TG vs. TT). We observed a moderately decreased risk of ovarian cancer based on 1829 cases and 2868 controls (pooled OR 0.85, 95% CI: 0.74-0.97; model, TG vs. TT). A slightly deceased risk of cancer was also indicated in Caucasians consisting of 6707 cases and 8279 controls (pooled OR 0.91, 95% CI: 0.85-0.98; model, TG vs. TT).These data suggest that carriage of a TG genotype at rs2066827 polymorphism may be associated with decreased susceptibility to cancer, ovarian cancer in particular.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Flow chart shows study selection process.
FIGURE 2
FIGURE 2
Forest plot for the association between the rs2066827 polymorphism and cancer risk (TG vs. TT model). Pooled odds ratio (OR) and 95% confidence interval (CI) have been appropriately derived from the fixed-effects model.
FIGURE 3
FIGURE 3
Forest plot for the association between the rs2066827 polymorphism and cancer risk by cancer type (TG vs. TT model). Pooled odds ratio (OR) and 95% confidence interval (CI) have been appropriately derived from the fixed-effects model.
FIGURE 4
FIGURE 4
Funnel plot of publication bias analysis for the associations between the rs2066827 polymorphism and cancer risk (TG vs. TT).
See this image and copyright information in PMC

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