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Case Reports
. 2016 Jan;101(1):10-1.
doi: 10.1210/jc.2015-3670. Epub 2015 Nov 18.

Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor

Anne Laure Coulon  1 , Frédérique Savagner  1 , Claire Briet  1 , Marie Vernin  1 , Mathilde Munier  1 , Olivier Chabre  1 , Patrice Rodien  1
Affiliations
Case Reports

Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor

Anne Laure Coulon et al. J Clin Endocrinol Metab. 2016 Jan.

Abstract

Context: Gestational thyrotoxicosis, whether associated with hyperemesis gravidarum or not, is thought to be due to excessive human chorionic gonadotropin (hCG) secretion.

Case description: We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG.

Conclusion: Severe and lasting gestational thyrotoxicosis with normal hCG concentration should lead to sequencing of the TSH receptor gene.

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