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. 2015 Dec 14;54(51):15330-3.
doi: 10.1002/anie.201509770. Epub 2015 Nov 19.

DNA Repair

Thomas Carell  1
Affiliations

DNA Repair

Thomas Carell. Angew Chem Int Ed Engl. .

Abstract

DNA is constantly damaged by various endogenous and exogenous events. Repair systems constantly scan the genome for DNA lesions and replace damaged and mismatched bases, which finally enables the complex DNA double strand to store genetic information. This year's Nobel Prize in Chemistry was awarded to pioneers in this field, T. Lindahl, P. Modrich, and A. Sancar.

Keywords: DNA damage; DNA repair; biochemistry; genetic information; medicinal chemistry.

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