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Clinical Trial
. 2015 Dec;4(4):e143-6.
doi: 10.1093/jpids/piu104. Epub 2014 Nov 12.

Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children

Ruth A Karron  1 , Jocelyn San Mateo  1 , Bhagvanji Thumar  1 , Anne Schaap-Nutt  2 , Ursula J Buchholz  2 , Alexander C Schmidt  2 , Emmalene J Bartlett  2 , Brian R Murphy  2 , Peter L Collins  2
Affiliations
Clinical Trial

Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children

Ruth A Karron et al. J Pediatric Infect Dis Soc. 2015 Dec.

Abstract

We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups: adults, HPIV-1-seropositive children, and HPIV-1-seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1-seropositive children but was overattenuated (ie, insufficiently infectious and immunogenic) for HPIV-1-seronegative children.

Keywords: HPIV-1 vaccine; children; lower respiratory tract illness.

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References

    1. Denny FW, Murphy TF, Clyde WA, Jr, et al. Croup: an 11-year study in a pediatric practice. Pediatrics 1983; 71:871–6. - PubMed
    1. Reed G, Jewett PH, Thompson J, et al. Epidemiology and clinical impact of parainfluenza virus infections in otherwise healthy infants and young children < 5 years old. J Infect Dis 1997; 175:807–13. - PubMed
    1. Schmidt AC, Schaap-Nutt A, Bartlett EJ, et al. Progress in the development of human parainfluenza virus vaccines. Expert Rev Respir Med 2011; 5:515–26. - PMC - PubMed
    1. Weinberg GA, Hall CB, Iwane MK, et al. Parainfluenza virus infection of young children: estimates of the population-based burden of hospitalization. J Pediatr 2009; 154:694–9. - PubMed
    1. Karron RA, Buchholz UJ, Collins PL. Live-attenuated respiratory syncytial virus vaccines. Curr Top Microbiol Immunol 2013; 372:259–84. - PMC - PubMed

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