Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Dec;29 Suppl 12(Suppl 12):S24-7.
doi: 10.1097/BOT.0000000000000459.

Stem Cell Therapies in Orthopaedic Trauma

Ralph S Marcucio  1 , Aaron Nauth, Peter V Giannoudis, Chelsea Bahney, Nicolas S Piuzzi, George Muschler, Theodore Miclau 3rd
Affiliations
Review

Stem Cell Therapies in Orthopaedic Trauma

Ralph S Marcucio et al. J Orthop Trauma. 2015 Dec.

Erratum in

  • J Orthop Trauma. 2016 Feb;30(2):e74

Abstract

Stem cells offer great promise to help understand the normal mechanisms of tissue renewal, regeneration, and repair, and also for development of cell-based therapies to treat patients after tissue injury. Most adult tissues contain stem cells and progenitor cells that contribute to homeostasis, remodeling, and repair. Multiple stem and progenitor cell populations in bone are found in the marrow, the endosteum, and the periosteum. They contribute to the fracture healing process after injury and are an important component in tissue engineering approaches for bone repair. This review focuses on current concepts in stem cell biology related to fracture healing and bone tissue regeneration, as well as current strategies and limitations for clinical cell-based therapies.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: All others have no conflicts.

References

    1. Muschler GF, Midura RJ. Connective tissue progenitors: Practical concepts for clinical applications. Clin Orthop Relat Res. 2002;(395):66–80. - PubMed
    1. Patterson TE, Kumagai K, Griffith L, Muschler GF. Cellular strategies for enhancement of fracture repair. J Bone Joint Surg Am. 2008;90(Suppl 1):111–9. - PubMed
    1. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy. 2006;8(4):315–7. - PubMed
    1. Colnot C, Zhang X, Knothe Tate ML. Current insights on the regenerative potential of the periosteum: Molecular, cellular, and endogenous engineering approaches. J Orthop Res. 2012;30(12):1869–78. - PMC - PubMed
    1. Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 2014;15(2):154–68. - PMC - PubMed

Publication types