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. 2015 Dec;17(12):962-71.
doi: 10.1007/s12094-015-1439-z. Epub 2015 Nov 19.

Clinical guideline seom: hereditary colorectal cancer

C Guillén-Ponce  1 , R Serrano  2 , A B Sánchez-Heras  3 , A Teulé  4 , I Chirivella  5 , T Martín  6 , E Martínez  7 , R Morales  8 , L Robles  9
Affiliations

Clinical guideline seom: hereditary colorectal cancer

C Guillén-Ponce et al. Clin Transl Oncol. 2015 Dec.

Abstract

Genetic mutations have been identified as the cause of inherited cancer risk in some colon cancer; these mutations are estimated to account for only 5-6 % of colorectal cancer (CRC) cases overall. Up to 25-30 % of patients have a family history of CRC that suggests a hereditary component, common exposures among family members, or a combination of both. Cancers in people with a hereditary predisposition typically occur at an earlier age than in sporadic cases. A predisposition to CRC may include a predisposition to other cancers, such as endometrial cancer. We describe genetics, current diagnosis and management of CRC hereditary syndromes pointing to a multidisciplinary approach to achieve the best results in patients and family outcomes.

Keywords: Adenomatous polyposis; Colon cancer; Hereditary colorectal cancer; Lynch syndrome.

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Figures

Fig. 1
Fig. 1
Lynch syndrome: diagnostic algorithm
Fig. 2
Fig. 2
Adenomatous polyposis: diagnostic algorithm. Grade of recommendation: B
See this image and copyright information in PMC

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