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Editorial
. 2016 Jan;23(1):1-2.
doi: 10.1038/cdd.2015.151. Epub 2015 Nov 20.

Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction

Affiliations
Editorial

Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction

A Linkermann et al. Cell Death Differ. 2016 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Post-infarct remodeling and heart failure. During MI, cardiomyocytes in the infarct zone die primarily by necrosis, much of which is regulated. This loss of functional muscle, which is complete in <24 h, activates a variety of stress pathways in non-infarcted areas of the heart, which induce long-term structural and functional changes, referred to collectively as adverse remodeling. Adverse remodeling precipitates additional contractile dysfunction within the non-infarcted myocardium. The molecular and cellular basis of these events is complex and involves dysfunction of cardiomyocytes and low-level, but ongoing, attrition of these cells through apoptosis. Shown are hematoxylin and eosin-stained cross-sections of mouse hearts 3d (left) and 7d (right) following surgical occlusion of the left coronary artery for 1 h followed by reperfusion in vivo. The infarct appears white. Dilation of the left ventricular (LV) cavity at the 7d time point reflects adverse remodeling. Images courtesy of Dr. Nikolaos G Frangogiannis.

Comment on

  • Cyclosporine before PCI in Patients with Acute Myocardial Infarction.
    Cung TT, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, Bonnefoy-Cudraz E, Guérin P, Elbaz M, Delarche N, Coste P, Vanzetto G, Metge M, Aupetit JF, Jouve B, Motreff P, Tron C, Labeque JN, Steg PG, Cottin Y, Range G, Clerc J, Claeys MJ, Coussement P, Prunier F, Moulin F, Roth O, Belle L, Dubois P, Barragan P, Gilard M, Piot C, Colin P, De Poli F, Morice MC, Ider O, Dubois-Randé JL, Unterseeh T, Le Breton H, Béard T, Blanchard D, Grollier G, Malquarti V, Staat P, Sudre A, Elmer E, Hansson MJ, Bergerot C, Boussaha I, Jossan C, Derumeaux G, Mewton N, Ovize M. Cung TT, et al. N Engl J Med. 2015 Sep 10;373(11):1021-31. doi: 10.1056/NEJMoa1505489. Epub 2015 Aug 30. N Engl J Med. 2015. PMID: 26321103 Clinical Trial.

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