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. 2015 Jun 1;4(12):e1052935.
doi: 10.1080/2162402X.2015.1052935. eCollection 2015 Dec.

ISG15: A double edged sword in cancer

Shyamal D Desai  1
Affiliations

ISG15: A double edged sword in cancer

Shyamal D Desai. Oncoimmunology. .

Abstract

Interferon-Stimulated Gene 15 (ISG15) transcript is aberrantly expressed in most human malignancies, suggesting that it has a protumor function. However, at the protein level ISG15 has both protumor and immunomodulatory antitumor functions. Therapeutic strategies to maximize the latter may benefit cancer patients overexpressing the ISG15 pathway.

Keywords: ISG15; cancer; immune system; immunostimulatory cytokine; ubiquitin/26S proteasome.

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Figures

Figure 1.
Figure 1.
The intracellular and extracellular functions of free ISG15.
See this image and copyright information in PMC

References

    1. Haas AL, Ahrens P, Bright PM, Ankel H. Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin. J Biol Chem 1987; 262:11315-23; PMID:2440890 - PubMed
    1. Bektas N, Noetzel E, Veeck J, Press MF, Kristiansen G, Naami A, Hartmann A, Dimmler A, Beckmann MW, Knüchel R, et al.. The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer. Breast Cancer Res 2008; 10:R58; PMID:18627608; http://dx.doi.org/10.1186/bcr2117 - DOI - PMC - PubMed
    1. Desai SD, Wood LM, Tsai YC, Hsieh TS, Marks JR, Scott GL, Giovanella BC, Liu LF. ISG15 as a novel tumor biomarker for drug sensitivity. Mol Cancer Ther 2008; 7:1430-9; PMID:18566215; http://dx.doi.org/10.1158/1535-7163.MCT-07-2345 - DOI - PMC - PubMed
    1. Desai SD, Haas AL, Wood LM, Tsai YC, Pestka S, Rubin EH, Saleem A, Nur-E-Kamal A, Liu LF. Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Cancer Res. 2006; 66:921-8; PMID:16424026; http://dx.doi.org/10.1158/0008-5472.CAN-05-1123 - DOI - PubMed
    1. Hershko A, Ciechanover A, Varshavsky A. Basic medical research award. The ubiquitin system. Nat Med 2000; 6:1073-81; PMID:11017125; http://dx.doi.org/10.1038/80384 - DOI - PubMed

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