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Review
. 1989:40:113-22.
doi: 10.1146/annurev.me.40.020189.000553.

Molecular pathogenesis of Ph-positive leukemias

S S Clark  1 , W M Crist, O N Witte
Affiliations
Review

Molecular pathogenesis of Ph-positive leukemias

S S Clark et al. Annu Rev Med. 1989.

Abstract

The strong association between the Philadelphia chromosome (Ph) and chronic myelogenous leukemia (CML) suggests that the Ph translocation plays a significant role in CML pathogenesis. For this reason, Ph-positive leukemias have been well studied from the molecular, clinical, and cell biological perspective. We attempt to integrate these data in order to better our understanding of the role of the Ph chromosome in human leukemia.

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