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Review
. 2015 Sep;3(2):141-7.
doi: 10.1159/000435901. Epub 2015 Aug 20.

Vasculopathy of Aging and the Revised Cardiovascular Continuum

Su-A Kim  1 , Jeong Bae Park  1 , Michael F O'Rourke  2
Affiliations
Review

Vasculopathy of Aging and the Revised Cardiovascular Continuum

Su-A Kim et al. Pulse (Basel). 2015 Sep.

Abstract

There have been attempts to explain the process of developments in overt cardiovascular disease, resulting in the presentation of the classic cardiovascular disease continuum and the aging cardiovascular continuum. Although the starting points of these two continua are different, they meet in the midstream of the cycle and reach a consensus at the end of the process. The announcement of the aging cardiovascular continuum made both continua complete, explaining the cardiovascular events in patients without atherosclerotic cardiovascular disease with aging. Impairment of the vascular structure by pulse wave and reflected wave is considered the cause of aortic damage, which influences the development of ischemic heart disease and the development of overt renal disease or cerebrovascular disease. The pathophysiology of vascular aging through pulse wave and its effect on other organs was discussed with Prof. Michael F. O'Rourke who devised the aging cardiovascular continuum.

Keywords: Aging; Artery; Cardiovascular disease; Pulse wave.

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Figures

Fig. 1
Fig. 1
Interaction of the traditional atherosclerotic cardiovascular continuum (left) and the aging continuum (right). CV = Cardiovascular; CAD = coronary artery disease; LVH = left ventricular hypertrophy; CHF = congestive heart failure.
None
See this image and copyright information in PMC

References

    1. O'Rourke MF, Safar ME, Dzau V. The cardiovascular continuum extended: aging effects on the aorta and microvasculature. Vasc Med. 2010;15:461–468. - PubMed
    1. Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes. 2. Clinical trial evidence (acute coronary syndromes through renal disease) and future directions. Circulation. 2006;114:2871–2891. - PubMed
    1. Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes. 1. Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease) Circulation. 2006;114:2850–2870. - PubMed
    1. Boutouyrie P, Laurent S, Benetos A, Girerd XJ, Hoeks AP, Safar ME. Opposing effects of ageing on distal and proximal large arteries in hypertensives. J Hypertens Suppl. 1992;10:S87–S92. - PubMed
    1. Virmani R, Avolio AP, Mergner WJ, Robinowitz M, Herderick EE, Cornhill JF, et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol. 1991;139:1119–1129. - PMC - PubMed

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