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Comment
. 2015 Nov 17;43(5):837-40.
doi: 10.1016/j.immuni.2015.10.026.

Common Characteristics of HIV-Neutralizing Antibodies with a Fondness for Sugars

Andrew T McGuire  1 , Leonidas Stamatatos  2
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Common Characteristics of HIV-Neutralizing Antibodies with a Fondness for Sugars

Andrew T McGuire et al. Immunity. .
Free article

Abstract

Broadly neutralizing antibodies targeting quaternary epitopes on the apex of the HIV-1 envelope spike are an attractive vaccine target, yet engineering immunogens that recapitulate such epitopes has proven difficult. In this issue of Immunity, Andrabi and colleagues (2015) identify an exciting new candidate immunogen that could initiate the production of these types of antibodies through vaccination.

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