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Editorial
. 2016 Jun;27(6):1577-9.
doi: 10.1681/ASN.2015101162. Epub 2015 Nov 20.

Cathepsin S-Dependent Protease-Activated Receptor-2 Activation: A New Mechanism of Endothelial Dysfunction

David J Nikolic-Paterson  1
Affiliations
Editorial

Cathepsin S-Dependent Protease-Activated Receptor-2 Activation: A New Mechanism of Endothelial Dysfunction

David J Nikolic-Paterson. J Am Soc Nephrol. 2016 Jun.
No abstract available

Keywords: PAR-2; cathepsin S; diabetic nephropathy; macrophage; therapy.

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References

    1. Nakagawa T, Tanabe K, Croker BP, Johnson RJ, Grant MB, Kosugi T, Li Q: Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol 7: 36–44, 2011 - PMC - PubMed
    1. Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC, Rollin BJ, Tesch GH: Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice. Kidney Int 69: 73–80, 2006 - PubMed
    1. de Zeeuw D, Bekker P, Henkel E, Hasslacher C, Gouni-Berthold I, Mehling H, Potarca A, Tesar V, Heerspink HJ, Schall TJ; CCX140-B Diabetic Nephropathy Study Group: The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: A randomised trial. Lancet Diabetes Endocrinol 3: 687–696, 2015 - PubMed
    1. Nguyen D, Ping F, Mu W, Hill P, Atkins RC, Chadban SJ: Macrophage accumulation in human progressive diabetic nephropathy. Nephrology (Carlton) 11: 226–231, 2006 - PubMed
    1. Kumar SVR, Darisipudi MN, Steiger S, Devarapu S, Tato M, Kukarni OP, Mulay SR, Thomasova D, Popper B, Demleitner J, Zuchtriegel G, Reichel C, Cohen CD, Lindenmeyer MT, Liapis H, Moll S, Reid E, Stitt AW, Schott B, Gruner S, Haap W, Ebeling M, Hartmann G, Anders H-J: Cathepsin S cleaving PAR-2 on endothelial cells promotes microvascular diabetes complications. J Am Soc Nephrol 27: 1635–1649, 2016 - PMC - PubMed

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