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Comment
. 2015 Nov 18;88(4):621-3.
doi: 10.1016/j.neuron.2015.11.007.

Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease

Allison E Girasole  1 , Alexandra B Nelson  2
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Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease

Allison E Girasole et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Shen et al. (2015) demonstrate that the M4 muscarinic receptor regulates striatal plasticity. The authors use an M4-positive allosteric modulator, which facilitates long-term depression in direct pathway neurons and reverses aberrant plasticity in levodopa-induced dyskinesia.

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