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doi: 10.1016/j.molcel.2015.11.005.
Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth
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- PMID: 26590709
- DOI: 10.1016/j.molcel.2015.11.005
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Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth
Mol Cell.
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Free article
Abstract
In this issue and the October 15th issue of Molecular Cell, studies by Montal et al. (2015) and Vincent et al. (2015) report that certain types of cancer cells utilize the gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) and phosphoenolpyruvate carboxykinase 2 (PCK2) to reprogram anabolic metabolism and support cell growth.
Copyright © 2015 Elsevier Inc. All rights reserved.
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Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.Mol Cell. 2015 Oct 15;60(2):195-207. doi: 10.1016/j.molcel.2015.08.013. Mol Cell. 2015. PMID: 26474064
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PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.Mol Cell. 2015 Nov 19;60(4):571-83. doi: 10.1016/j.molcel.2015.09.025. Epub 2015 Oct 17. Mol Cell. 2015. PMID: 26481663 Free PMC article.
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