Radionuclide Assessment of Left Ventricular Dyssynchrony

Abstract

Phase analysis of gated myocardial perfusion single-photon emission computed tomography is a widely available and reproducible measure of left ventricular (LV) dyssynchrony, which also provides comprehensive assessment of LV function, global and regional scar burden, and patterns of LV mechanical activation. Preliminary studies indicate potential use in predicting cardiac resynchronization therapy response and elucidation of mechanisms. Because advances in technology may expand capabilities for precise LV lead placement in the future, identification of specific patterns of dyssynchrony may have a critical role in guiding cardiac resynchronization therapy.

Keywords: Cardiac resynchronization therapy; Echo; Heart failure; LBBB; Left ventricular dyssynchrony; Myocardial scar; QRS; Radionuclide; SPECT; Site of latest activation.