Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015 Nov 23:17:326.
doi: 10.1186/s13075-015-0817-9.

Cross-talk between bone morphogenetic proteins and inflammatory pathways

Peter M van der Kraan  1 , Esmeralda N Blaney Davidson  2
Affiliations
Editorial

Cross-talk between bone morphogenetic proteins and inflammatory pathways

Peter M van der Kraan et al. Arthritis Res Ther. .

Abstract

Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and developmental biology. Varas and colleagues report that these factors show cross-talk in rheumatoid arthritis synoviocytes. They show that pro-inflammatory cytokines not only stimulate the production of bone morphogenetic proteins but that these endogenously produced bone morphogenetic proteins interfere with the effects of pro-inflammatory cytokines on synoviocytes.

PubMed Disclaimer

Comment on

References

    1. Varas A, Valencia J, Lavocat F, Martínez VG, Thiam NN, Hidalgo L, et al. Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes. Arthritis Res Ther. 2015;17:192. doi: 10.1186/s13075-015-0710-6. - DOI - PMC - PubMed
    1. Brennan FM, Maini RN, Feldmann M. TNF alpha—a pivotal role in rheumatoid arthritis? Br J Rheumatol. 1992;31:293–8. doi: 10.1093/rheumatology/31.5.293. - DOI - PubMed
    1. van den Berg WB, Miossec P. IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol. 2009;5:549–53. doi: 10.1038/nrrheum.2009.179. - DOI - PubMed
    1. Roeleveld DM, Koenders MI. The role of the Th17 cytokines IL-17 and IL-22 in rheumatoid arthritis pathogenesis and developments in cytokine immunotherapy. Cytokine. 2015;74:101–7. doi: 10.1016/j.cyto.2014.10.006. - DOI - PubMed
    1. Bier E, De Robertis EM. BMP gradients: a paradigm for morphogen-mediated developmental patterning. Science. 2015;348:aaa5838. doi: 10.1126/science.aaa5838. - DOI - PubMed

MeSH terms