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. 2016 Jan 11;55(2):579-82.
doi: 10.1002/anie.201508572. Epub 2015 Nov 23.

Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor

Ryosuke Ueki  1 , Ayaka Ueki  1 , Naoto Kanda  1 , Shinsuke Sando  2
Affiliations

Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor

Ryosuke Ueki et al. Angew Chem Int Ed Engl. .

Abstract

Oligonucleotide-based hepatocyte growth factor (HGF) mimetics are described. A DNA aptamer to Met, a cognate receptor for HGF, was shown to induce Met activation when used in dimer form. The most potent aptamer dimer, ss-0, which was composed solely of 100-mer single-stranded DNA, exhibited nanomolar potency. Aptamer ss-0 reproduced HGF-induced cellular behaviors, including migration and proliferation. The present work sheds light on oligonucleotides as a novel chemical entity for the design of growth factor mimetics.

Keywords: DNA nanotechnology; aptamers; growth factors; receptors; signal transduction.

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