Oxygen Saturation Targeting and Bronchopulmonary Dysplasia

Abstract

Oxygen saturation targeting is widely used in neonatal intensive care, but the optimal target range in very preterm infants has been uncertain and is the subject of recent debate and research. This review briefly discusses the technology of oxygen monitoring and the role of oxygen toxicity in preterm infants. The background to the recent trials of oxygen saturation targeting in acute and continuing care of very preterm infants is reviewed, and the findings and implications of the recent trials, particularly with respect to bronchopulmonary dysplasia, are discussed.

Keywords: Bronchopulmonary dysplasia; Neonatal free radical disease; Oxygen saturation; Randomized controlled trial; Retinopathy of prematurity; Very preterm infant.