Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Dec;36(4):569-84.
doi: 10.1016/j.ccm.2015.08.002. Epub 2015 Oct 1.

Genetics of Sarcoidosis

Tasha E Fingerlin  1 , Nabeel Hamzeh  2 , Lisa A Maier  2
Affiliations
Review

Genetics of Sarcoidosis

Tasha E Fingerlin et al. Clin Chest Med. 2015 Dec.

Abstract

Sarcoidosis is a disease with highly variable presentation and progression; although it is hypothesized that disease phenotype is related to genetic variation, how much of this variability is driven by genetic factors is not known. The HLA region is the most strongly and consistently associated genetic risk factor for sarcoidosis, supporting the notion that sarcoidosis is an exposure-mediated immunologic disease. Most of the genetic etiology of sarcoidosis remains unknown in terms of the specific variants that increase risk in various populations, their biologic functions, and how they interact with environmental exposures.

Keywords: Genetic epidemiology; HLA region; Immune-mediated disease; Sarcoidosis.

PubMed Disclaimer