Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul;24(3):107-33.
doi: 10.1297/cpe.24.107. Epub 2015 Jul 18.

Guidelines for Mass Screening of Congenital Hypothyroidism (2014 revision)

Mass Screening Committee; Japanese Society for Pediatric Endocrinology; Japanese Society for Mass Screening; Keisuke Nagasaki  1 , Kanshi Minamitani  2 , Makoto Anzo  3 , Masanori Adachi  4 , Tomohiro Ishii  5 , Kazumichi Onigata  6 , Satoshi Kusuda  7 , Shohei Harada  8 , Reiko Horikawa  9 , Masanori Minagawa  1 , Haruo Mizuno  10 , Yuji Yamakami  11 , Masaru Fukushi  12 , Toshihiro Tajima  13
Affiliations

Guidelines for Mass Screening of Congenital Hypothyroidism (2014 revision)

Mass Screening Committee et al. Clin Pediatr Endocrinol. 2015 Jul.

Abstract

Purpose of developing the guidelines: Mass screening for congenital hypothyroidism started in 1979 in Japan, and the prognosis for intelligence has been improved by early diagnosis and treatment. The incidence was about 1/4000 of the birth population, but it has increased due to diagnosis of subclinical congenital hypothyroidism. The disease requires continuous treatment, and specialized medical facilities should make a differential diagnosis and treat subjects who are positive in mass screening to avoid unnecessary treatment. The Guidelines for Mass Screening of Congenital Hypothyroidism (1998 version) were developed by the Mass Screening Committee of the Japanese Society for Pediatric Endocrinology in 1998. Subsequently, new findings on prognosis and problems in the adult phase have emerged. Based on these new findings, the 1998 guidelines were revised in the current document (hereinafter referred to as the Guidelines). Target disease/conditions: Primary congenital hypothyroidism. Users of the Guidelines: Physician specialists in pediatric endocrinology, pediatric specialists, physicians referring patients to pediatric practitioners, general physicians, laboratory technicians in charge of mass screening, and patients.

Keywords: congenital hypothyroidism; guideline; mass screening.

PubMed Disclaimer

References

    1. Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010. 10;5:17. doi: 10.1186/1750-1172-5-1. - DOI - PMC - PubMed
    1. Grosse SD, Van Vliet G. Prevention of intellectual disability through screening for congenital hypothyroidism: how much and at what level? Arch Dis Child 2011;96: 374–9. doi: 10.1136/adc.2010.190280 - DOI - PubMed
    1. Nakajima H, Satoh K, Inomata H, Matsuura N, Igarashi H, et al. National study of mental development of patients with congenital hypothyroidism disclosed by neonatal mass screening. J Jpn Pediatr Soc 1989;93: 2011–6 (in Japanese).
    1. Niimi H. Neonatal screening for congenital hypothyrodism and hyperthyrotropinemia without hypothyroxinemia. Clin Pediatr Endocrinol 1994;3: 73–7. doi: 10.1297/cpe.3.73 - DOI
    1. Inomata H, Aoki K. National survey of congenital hypothyroidism detected by neonatal mass screening (1994-1999). Jpn J Mass Screening 2003;13: 27–32 (in Japanese).

LinkOut - more resources