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Review
. 2015 Nov 10;8(1):31.
doi: 10.1186/s40413-015-0079-7. eCollection 2015.

Allergen Immunotherapy (AIT): a prototype of Precision Medicine

G W Canonica  1 , C Bachert  2 , P Hellings  3 , D Ryan  4 , E Valovirta  5 , M Wickman  6 , O De Beaumont  7 , J Bousquet  8
Affiliations
Review

Allergen Immunotherapy (AIT): a prototype of Precision Medicine

G W Canonica et al. World Allergy Organ J. .

Abstract

Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to the specific IgE spectrum of an individual and modifies the natural course of the disease as it has a persistent efficacy after completion of treatment. In this perspective Allergen Immunotherapy - AIT has to be presently considered a prototype of Precision Medicine. Precise information and biomarkers provided by systems medicine and network medicine will address the discovery of Allergen immunotherapy biomarkers for (i) identification of the causes, (ii) stratification of eligible patients for AIT and (iii) the assessment of AIT efficacy. This area of medical technology is evolving rapidly and, compelemented by e-health, will change the way we practice medicine. It will help to monitor patients' disease control and data for (i) patient stratification, (ii) clinical trials, (iii) monitoring the efficacy and safety of targeted therapies which are critical for reaching an appropriate reimbursement. Biomarkers associated with e-health combined with a clinical decision support system (CDSS) will change the scope of Allergen immunotherapy. The cost/effectiveness of Allergen immunotherapy is a key issue for successful implementation. It should include the long-term benefits in the pharmaco-economic evaluation, since no other allergy treatment has this specific characteristic. AIT is the prototype of current and future precision medicine.

Keywords: AIT; Allergen immunotherapy; Allergy; Personalized medicine; Precision medicine.

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Figures

Fig. 1
Fig. 1
The three steps of personalised (precision) medicine (modified from [2])
Fig. 2
Fig. 2
The three steps of Personalised (Precision) Medicine applied to AIT
Fig. 3
Fig. 3
Critical issues on precision medicine in AIT
Fig. 4
Fig. 4
Flow of precision medicine approach in allergic disease
See this image and copyright information in PMC

References

    1. Paving the way for personalizdd medicine, FDA’s role in a new era of medical product development. http://www.fdagov/downloads/ScienceResearch/SpecialTopics/PersonalizedMe.... 2013
    1. Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med. 2010;363(4):301–4. doi: 10.1056/NEJMp1006304. - DOI - PubMed
    1. Bousquet J, Jorgensen C, Dauzat M, Cesario A, Camuzat T, Bourret R, et al. Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies. Curr Pharm Des. 2014;20(38):5928–44. doi: 10.2174/1381612820666140314115505. - DOI - PubMed
    1. Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, Drevinek P, et al. A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med. 2011;365(18):1663–72. doi: 10.1056/NEJMoa1105185. - DOI - PMC - PubMed
    1. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372(9):793–5. doi: 10.1056/NEJMp1500523. - DOI - PMC - PubMed

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