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Comment
. 2015 Dec;25(12):1283-4.
doi: 10.1038/cr.2015.135. Epub 2015 Nov 24.

RNA editing by ADAR1 marks dsRNA as "self"

Zhou Yu  1 , Taoyong Chen  2 , Xuetao Cao  1   2
Affiliations
Comment

RNA editing by ADAR1 marks dsRNA as "self"

Zhou Yu et al. Cell Res. 2015 Dec.

Abstract

A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.

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Figures

Figure 1
Figure 1
ADAR1-mediated A-to-I editing of endogenous dsRNA. In the presence of ADAR1, endogenous dsRNA is edited and regarded as self dsRNA that does not initiate immunogenic MDA5 recognition. In case of ADAR1 deficiency or mutation, endogenous dsRNA is recognized by MDA5 as non-self, and then activates MAVS-dependent phosphorylation of IFN-regulatory factor 7 (IRF7) and induction of IFNs, probably leading to the pathogenesis of autoimmune diseases.
See this image and copyright information in PMC

Comment on

References

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