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Comment
. 2015 Dec;21(12):731-733.
doi: 10.1016/j.molmed.2015.10.006. Epub 2015 Nov 17.

Bioengineered FSTL1 Patches Restore Cardiac Function Following Myocardial Infarction

Ann-Kristin Alteköester  1 , Richard P Harvey  2
Affiliations
Comment

Bioengineered FSTL1 Patches Restore Cardiac Function Following Myocardial Infarction

Ann-Kristin Alteköester et al. Trends Mol Med. 2015 Dec.

Abstract

Improving the limited ability of the heart to regenerate after infarction is crucial. Researchers now demonstrate that delivery of follistatin-like 1 (FSTL1) into injured hearts via collagen patches stimulates cardiomyocyte proliferation and cardiac functional recovery. These findings highlight the epicardium as a source of novel regenerative factors and biomimetic nanomaterials in cardiac translational medicine.

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Comment in

  • Overexpressing FSTL1 for Heart Repair.
    Sanchis-Gomar F, Perez-Quilis C, Lucia A. Sanchis-Gomar F, et al. Trends Mol Med. 2016 May;22(5):353-354. doi: 10.1016/j.molmed.2016.03.003. Epub 2016 Mar 26. Trends Mol Med. 2016. PMID: 27025407 No abstract available.

Comment on

  • Epicardial FSTL1 reconstitution regenerates the adult mammalian heart.
    Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P. Wei K, et al. Nature. 2015 Sep 24;525(7570):479-85. doi: 10.1038/nature15372. Epub 2015 Sep 16. Nature. 2015. PMID: 26375005 Free PMC article.

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