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Comparative Study
. 2015 Nov 24:5:16927.
doi: 10.1038/srep16927.

Value of TIRADS, BSRTC and FNA-BRAF V600E mutation analysis in differentiating high-risk thyroid nodules

Yu-zhi Zhang  1 , Ting Xu  1 , Dai Cui  1 , Xiao Li  2 , Qing Yao  2 , Hai-yan Gong  3 , Xiao-yun Liu  1 , Huan-huan Chen  1 , Lin Jiang  1 , Xin-hua Ye  3 , Zhi-hong Zhang  2 , Mei-ping Shen  4 , Yu Duan  1 , Tao Yang  1 , Xiao-hong Wu  1
Affiliations
Comparative Study

Value of TIRADS, BSRTC and FNA-BRAF V600E mutation analysis in differentiating high-risk thyroid nodules

Yu-zhi Zhang et al. Sci Rep. .

Abstract

The thyroid imaging reporting and data system (TIRADS) and Bethesda system for reporting thyroid cytopathology (BSRTC) have been used for interpretation of ultrasound and fine-needle aspiration cytology (FNAC) results of thyroid nodules. BRAF(V600E) mutation analysis is a molecular tool in diagnosing thyroid carcinoma. Our objective was to compare the diagnostic value of these methods in differentiating high-risk thyroid nodules. Total 220 patients with high-risk thyroid nodules were recruited in this prospective study. They all underwent ultrasound, FNAC and BRAF(V600E) mutation analysis. The sensitivity and specificity of TIRADS were 73.1% and 88.4%. BSRTC had higher specificity (97.7%) and similar sensitivity (77.6%) compared with TIRADS. The sensitivity and specificity of BRAF(V600E) mutation (85.1%, 100%) were the highest. The combination of BSRTC and BRAF(V600E) mutation analysis significantly increased the efficiency, with 97.8% sensitivity, 97.7% specificity. In patients with BSRTC I-III, the mutation rate of BRAF(V600E) was 64.5% in nodules with TIRADS 4B compared with 8.4% in nodules with TIRADS 3 or 4A (P < 0.001). Our study indicated that combination of BSRTC and BRAF(V600E) mutation analysis bears a great value in differentiating high-risk thyroid nodules. The TIRADS is useful in selecting high-risk patients for FNAB and patients with BSRTC I-III for BRAF(V600E) mutation analysis.

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Figure 1
Figure 1. Diagram of the study group.
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References

    1. Gharib H. et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and EuropeanThyroid Association Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules. Endocr Pract 16 Suppl 1, 1 (2010). - PubMed
    1. Brito J. P. et al. The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis. J Clin Endocrinol Metab 99(4), 1253 (2014). - PMC - PubMed
    1. Moon W. J. et al. Benign and malignant thyroid nodules: US differentiation—multicenter retrospective study. Radiology 247(3), 762 (2008). - PubMed
    1. Ozel A. et al. The diagnostic efficiency of ultrasound in characterization for thyroid nodules: how many criteria are required to predict malignancy? Med Ultrason 14(1), 24 (2012). - PubMed
    1. Horvath E. et al. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J Clin Endocrinol Metab 94(5), 1748 (2009). - PubMed

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