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. 2015 Nov 23:8:703.
doi: 10.1186/s13104-015-1693-8.

Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation

Abdulrahim Gari  1
Affiliations

Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation

Abdulrahim Gari. BMC Res Notes. .

Abstract

Background: Mixed trophoblastic tumor composed of choriocarcinoma and placental site trophoblastic tumor was diagnosed on histopathology slides review, is a very rare mixed tumor and cured after adjuvant chemotherapy.

Case presentation: Twenty-nine years old, Para 2 female presented with 4 months history of irregular vaginal bleeding after an uncomplicated vaginal delivery. Abdominal examination showed 14 weeks uterus with β-hCG level of 14,889 mIU/ml. Slides review confirmed the diagnosis of placental site trophoblastic tumor (PSTT). Patient underwent total abdominal hysterectomy and resection of anterior vaginal wall mass. Post operative (48 h) β-hCG level was 6016 mIU/ml. Final pathology showed mixed trophoblastic tumor composed of choriocarcinoma (CC) and PSTT. Adjuvant chemotherapy started and continued for three cycles after achieving normal β-hCG.

Conclusion: PSTT is a rare disease and potentially curable. Differential diagnosis in women presented with vaginal bleeding and a uterine mass in the post partum period must include gestational trophoblastic disease.

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Figures

Fig. 1
Fig. 1
Uterus with multiple areas of impending tumor perforation with resected anterior vaginal mass
Fig. 2
Fig. 2
a Hematoxylin and eosin (H & E) stain showing dimorphic picture of syncythiotrophoblast and cytotrophoblast in Choriocarcinoma; b β-Human Chorionic Gonadotrophin immunohistochemical stain showing positive staining in Choriocarcinoma componants; c H & E Stain showing sheets of monomorphic intermediate trophoblasts and fibrinoid material in placental site trophoblastic tumor; d Immunohistochemistry (IHC): hPL immunostain showing positive staining in intermediate trophoblasts of placental site trophoblastic tumor; e IHC: Inhibin immunostain showing positive staining in intermediate trophoblasts of placental site trophoblastic tumor; f IHC: β-HCG immunostain showing negative staining in intermediate trophoblasts of placental site trophoblastic tumor
See this image and copyright information in PMC

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