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Review
. 2015 Dec;48(6):611-25.
doi: 10.1111/cpr.12216.

Cervical cancer stem cells

Tingting Yao  1   2 , Rongbiao Lu  3 , Yizhen Zhang  4 , Ya Zhang  4 , Chenyang Zhao  4 , Rongchun Lin  1 , Zhongqiu Lin  1
Affiliations
Review

Cervical cancer stem cells

Tingting Yao et al. Cell Prolif. 2015 Dec.

Abstract

The concept of cancer stem cells (CSC) has been established over the past decade or so, and their role in carcinogenic processes has been confirmed. In this review, we focus on cervical CSCs, including (1) their purported origin, (2) markers used for cervical CSC identification, (3) alterations to signalling pathways in cervical cancer and (4) the cancer stem cell niche. Although cervical CSCs have not yet been definitively identified and characterized, future studies pursuing them as therapeutic targets may provide novel insights for treatment of cervical cancer.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Image of cervical cancer lesion.
Figure 2
Figure 2
Transformation zone as the niche of cervical cancer stem cells.
Figure 3
Figure 3
Illustration of the two shocks of cervical cancer stem cells.
Figure 4
Figure 4
HPV E6 and E7 oncoproteins and p53, p21 and Rb tumour suppressor proteins.
Figure 5
Figure 5
SHH pathway (cited from Sheridan C (2009) Genentech obtains proof of concept for hedgehog inhibition. Nat. Biotechnol. 27 , 968–969).
Figure 6
Figure 6
Receptors and ligands of Notch pathway (cited from Maillard I, Fang T, Pear WS (2005) Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu. Rev. Immunol. 23, 945–974).
Figure 7
Figure 7
Relationship between cervical cancer and Wnt pathway (cited from Rath G, Jawanjal P, Salhan S, Nalliah M, Dhawan I (2015) Clinical significance of inactivated glycogen synthase kinase 3beta in HPV‐associated cervical cancer: Relationship with Wnt/beta‐catenin pathway activation. Am. J. Reprod. Immunol. 73, 460–478).
See this image and copyright information in PMC

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