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Published Erratum
. 2015 Dec 1;112(48):E6719.
doi: 10.1073/pnas.1519997112. Epub 2015 Nov 23.

Correction for Sharma et al., In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

No authors listed
Published Erratum

Correction for Sharma et al., In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

No authors listed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 4.
Fig. 4.
(A) Comparison of the average and SD of various properties, i.e., SASA, RMSF, and SASA (n + 1, N), extracted from MD simulations for labile group (red) vs. stable group of Asp residues (green). Calculated P values are shown on each plot. (B) Outcome of the logistical regression to enable prediction of labile vs. stable Asp sites. Logistic regression was performed using SASA, RMSF, and SASA (n + 1, N) as independent variables and the binary rate output as the dependent variable. All sites were assigned a value of 1 or 0 for labile and stable sites, respectively, based on a cutoff value of Asp degradation rate of 2.5%/wk at pH 5.5. Labile residues are shown in red and stable residues are shown in green. The predicted outcome was generated using the binary logistic model as described in the text. The model was validated using the LOOCV approach.
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