Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Dec;31(12):696-708.
doi: 10.1016/j.tig.2015.10.004.

The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

Douglas Vernimmen  1 , Wendy A Bickmore  2
Affiliations
Free article
Review

The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

Douglas Vernimmen et al. Trends Genet. 2015 Dec.
Free article

Abstract

Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.

PubMed Disclaimer

Publication types

MeSH terms