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Review
. 2015 Aug;10(4):259-64.
doi: 10.1159/000437452. Epub 2015 Aug 19.

Radiotherapy of Ductal Carcinoma In Situ

Affiliations
Review

Radiotherapy of Ductal Carcinoma In Situ

David Krug et al. Breast Care (Basel). 2015 Aug.

Abstract

Ductal carcinoma in situ (DCIS) is a heterogeneous disease in both its biology and clinical course. In the past, recurrence rates after breast-conserving surgery have been as high as 30% after 10 years. The introduction of mammography screening and advances in imaging have led to an increase in the detection of DCIS. The focus of this review is on the role of radiotherapy in the multidisciplinary treatment, including current developments in hypofractionation and boost delivery, and attempts to define low-risk subsets of DCIS for which the need for adjuvant radiation is repeatedly questioned.

Keywords: Boost; Ductal carcinoma in situ (DCIS); Hypofractionation; Low-risk subgroup; Radiotherapy.

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References

    1. Lynge E, Ponti A, James T, et al. Variation in detection of ductal carcinoma in situ during screening mammography: A survey within the international cancer screening network. Eur J Cancer. 2014;50:185–192. - PMC - PubMed
    1. Souchon R, Sautter-Bihl ML, Sedlmayer F, et al. DEGRO practical guidelines: Radiotherapy of breast cancer II: Radiotherapy of non-invasive neoplasia of the breast. Strahlenther Onkol. 2014;190:8–16. - PubMed
    1. Early Breast Cancer Trialists' Collaborative Group. Correa C, McGale P, et al. Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr. 2010;2010:162–177. - PMC - PubMed
    1. Warnberg F, Garmo H, Emdin S, et al. Effect of radiotherapy after breast-conserving surgery for ductal carcinoma in situ: 20 years follow-up in the randomized SweDCIS trial. J Clin Oncol. 2014;32:3613–3618. - PubMed
    1. Bekelman JE, Sylwestrzak G, Barron J, et al. Uptake and costs of hypofractionated vs conventional whole breast irradiation after breast conserving surgery in the United States, 2008-2013. JAMA. 2014;312:2542–2550. - PMC - PubMed