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. 1989 Jun;86(12):4634-8.
doi: 10.1073/pnas.86.12.4634.

Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family

M van de Rijn  1 , S Heimfeld, G J Spangrude, I L Weissman
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Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family

M van de Rijn et al. Proc Natl Acad Sci U S A. 1989 Jun.

Abstract

Recently, hematopoietic stem cells were purified to homogeneity from mouse bone marrow. The protein structure of Sca-1, the cell surface antigen used in the isolation of hematopoietic stem cells, is described here. It is shown that the Sca-1 antigen is a member of the Ly-6 antigen family. The anti-Sca-1 antibody was used in immunohistochemistry experiments to define the structures in several tissues that had previously been shown to contain Ly-6 antigens. In thymus, spleen, and kidney, specific staining of parenchymal cells can be demonstrated, whereas only vasculature reacts with anti-Sca-1 in brain, heart, and liver and possibly in lung.

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