Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes

Abstract

Aging research is a multi-disciplinary field encompassing knowledge from many areas of basic, applied and clinical research. Age-related processes occur on molecular, cellular, tissue, organ, system, organismal and even psychological levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, and there is a need for a unified knowledge repository designed to track, analyze and visualize the cause and effect relationships and interactions between the many elements and processes on all levels. Aging Chart (http://agingchart.org/) is a new, community-curated collection of aging pathways and knowledge that provides a platform for rapid exploratory analysis. Building on an initial content base constructed by a team of experts from peer-reviewed literature, users can integrate new data into biological pathway diagrams for a visible, intuitive, top-down framework of aging processes that fosters knowledge-building and collaboration. As the body of knowledge in aging research is rapidly increasing, an open visual encyclopedia of aging processes will be useful to both the new entrants and experts in the field.

Figure 1.

Example of the mTOR pathway presented in editable format and linked to multiple information resources. Pop-ups appear upon clicking each node with links to PubMed references and other relevant Aging Chart pathways. Mini-reviews are found at the bottom of each pathway page and summarize pathway information with current peer-reviewed literature and PubMed links.