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Case Reports
. 2015 May-Aug;19(2):266.
doi: 10.4103/0973-029X.164555.

Histopathological spectrum of polymorphous low-grade adenocarcinoma

Varun Surya  1 , Jagdish V Tupkari  1 , Tabita Joy  1 , Priyanka Verma  2
Affiliations
Case Reports

Histopathological spectrum of polymorphous low-grade adenocarcinoma

Varun Surya et al. J Oral Maxillofac Pathol. 2015 May-Aug.

Abstract

Polymorphous low-grade adenocarcinomas (PLGA) are distinctive salivary gland neoplasms, with an almost exclusive propensity to arise from the minor salivary glands. PLGA frequently manifests as an asymptomatic, slow-growing mass within the oral cavity, which must be separated from adenoid cystic carcinoma and benign mixed tumor for therapeutic and prognostic considerations. We report a case of a 67-year-old male, who presented with a long-standing mass in the palate. This lesion was diagnosed as PLGA based on histopathological findings, which was further confirmed by the immunohistochemical marker.

Keywords: Adenoid cystic carcinoma; minor salivary glands; polymorphous low-grade adenocarcinoma.

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Figures

Figure 1
Figure 1
Intra-oral photograph showing a solitary, well-defined, dome-shaped swelling with bluish hue on the left postero-lateral part of the palate
Figure 2
Figure 2
No significant bony changes noticed on orthopantomography
Figure 3
Figure 3
The magnetic resonance imaging report revealed focally expansile mass in the left half of the posterior third of the hard palate and adjacent superior alveolus, with a thin shell of intact cortical bone separating the mass from the maxillary sinus
Figure 4
Figure 4
Lesional tissue comprising of glandular tissue separated by fibrous septa. Note-normal surface epithelium with lamina propria separating the lesional tissue (H&E stain, ×40)
Figure 5
Figure 5
(a) Tumor cell arranged in a cribriform architectural pattern (H&E stain, ×100). (b) Tumor cell arranged in a ductal pattern (H&E stain, ×100). (c) Tumor tissue with mucoid pool and hemorrhagic areas (H&E stain, ×100)
Figure 6
Figure 6
Uniform round to polygonal tumor cells with indistinct cell borders and vesiculated nucleus (H&E stain, ×400)
Figure 7
Figure 7
At the tumor periphery, the cells are arranged in a linear, single cell pattern resembling “Indian file” or beads on a string pattern of infiltration (H&E stain, ×100)
Figure 8
Figure 8
(a) Immunohistochemical staining with vimentin showing a strong positive reaction(IHC stain, x100). (b) Higher magnification of vimentin staining showing strong positive reaction in the lesional cells. (IHC stain, x400)
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References

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