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Case Reports
. 2015 May-Aug;19(2):270.
doi: 10.4103/0973-029X.164566.

Diffuse large B-cell lymphoma (extranodal) of maxillary buccal vestibule

Ashok V Patil  1 , Rashmi B Deshpande  1 , Shilpa M Kandalgaonkar  1 , Mahesh H Gabhane  1
Affiliations
Case Reports

Diffuse large B-cell lymphoma (extranodal) of maxillary buccal vestibule

Ashok V Patil et al. J Oral Maxillofac Pathol. 2015 May-Aug.

Abstract

Lymphomas are the group of neoplasms originating from lymphoreticular system mainly from lymph nodes, among them up to 40% of non-Hodgkin's lymphomas present extra nodally. In oral cavity, lymphomas are least common and account for 3-5% of all malignancies, presenting mainly in older age groups with male predominance. According to Revised European-American Lymphoma classification, among B-cell and T-cell subtypes of non-Hodgkin's lymphomas, diffuse large B-cell lymphoma (DLBCL) is the most common, characterized by diffuse proliferation of large neoplastic B lymphoid cells. Here we present a case report of DLBCL affecting oral cavity involving left buccal vestibule and extending onto the palate, along with its clinical, histopathologic and immunohistochemical features.

Keywords: B-cell lymphoma; diffuse large B cell lymphoma; left buccal vestibule; non-Hodgkin's lymphomas.

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Figures

Figure 1
Figure 1
Clinical image shows diffuse, roughly oval shape swelling situated in maxillary buccal vestibule
Figure 2
Figure 2
Radiographic images shows haziness in left maxillary sinus region
Figure 3
Figure 3
Histopathological image shows diffuse monotonous proliferation of round cells in the form of sheets within a loose fibrillar stroma (H&E stain, ×100)
Figure 4
Figure 4
Histopathological image shows round centroblastic cells with large nuclei (H&E stain, ×400)
Figure 5
Figure 5
Histopathological image shows round immunoblastic cells (H&E stain, ×400)
Figure 6
Figure 6
Immunohistochemical image shows strong positivity for CD45 (IHC stain, ×100)
Figure 7
Figure 7
Immunohistochemical image shows strong positivity for CD20 (IHC stain, ×100)
See this image and copyright information in PMC

References

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