Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

Abstract

Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of irinotecan. After irinotecan was introduced for the treatment of metastatic colorectal cancer (CRC) at the end of the last century, survival has improved dramatically. Irinotecan is now combined with 5-fluorouracil, oxaliplatin and several molecularly-targeted anticancer drugs, resulting in the extension of overall survival to longer than 30 mo. Severe, occasionally life-threatening toxicity occurs sporadically, even in patients in relatively good condition who have a low risk of chemotherapy-induced toxicity, often causing the failure of irinotecan-based chemotherapy. Clinical pharmacological studies have revealed that such severe toxicity is related to exposure to SN-38 and genetic polymorphisms in UDP-glucuronosyltransferase 1A1 gene. The large inter- and intra-patient variability in systemic exposure to SN-38 is determined not only by genetic factors but also by physiological and environmental factors. This review first summarizes the roles of irinotecan in chemotherapy for metastatic CRC and then discusses the optimal dosing of irinotecan based on the aforementioned factors affecting systemic exposure to SN-38, with the ultimate goal of achieving personalized irinotecan-based chemotherapy.

Keywords: Dosing; Irinotecan; Metastatic colorectal cancer; Personalized chemotherapy; Severe renal failure; Survival advantage.

Figure 1

Extension of overall survival and development of chemotherapy regimens in metastatic colorectal cancer. 5-FU: 5-fluorouracil; LV: Leucovorin; FOLFIRI: Irinotecan, bolus 5-FU/LV and infusional 5-FU; FOLFOX: Oxaliplatin, bolus 5-FU/LV and infusional 5-FU; FOLFOXIRI: Irinotecan, oxaliplatin, bolus 5-FU/LV and infusional 5-FU.