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. 2016 Feb:40:15-21.
doi: 10.1016/j.canep.2015.10.026. Epub 2015 Nov 21.

Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk

Aimee L Lucas  1 , Francesca Bravi  2 , Paolo Boffetta  3 , Jerry Polesel  4 , Diego Serraino  4 , Carlo La Vecchia  5 , Cristina Bosetti  2
Affiliations

Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk

Aimee L Lucas et al. Cancer Epidemiol. 2016 Feb.

Abstract

Background: Pancreatic cancer is a leading cause of cancer death. A role of dietary factors in pancreatic carcinogenesis has been suggested. The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) published 8 recommendations for cancer prevention. We evaluated the effect of adherence to the WCRF/AICR recommendations on pancreatic cancer risk.

Methods: We operationalized 7 of the 8 WCRF/AICR recommendations to generate a WCRF/AICR score. We examined the association of WCRF/AICR score with pancreatic cancer in data from an Italian case-control study of 326 incident cases and 652 controls.

Results: Adherence to WCRF/AICR recommendations was associated with a significantly decreased risk of pancreatic cancer. Using a WCRF/AICR score <3.5 as a reference, the adjusted odds ratio (OR) for a score 3.5-<4 was 0.80 (95% CI 0.49, 1.28), for a score 4-<5 0.54 (95% CI 0.35, 0.82), and for score 5 or more 0.41 (95% CI 0.24, 0.68; p-value for trend 0.0002). The OR for a continuous increment of one unit of the WCRF/AICR score was 0.72 (95% CI 0.60, 0.87).

Conclusion: Adherence to the WCRF/AICR recommendations may reduce pancreatic cancer risk.

Keywords: American Institute for Cancer Research; Diet; Pancreatic cancer; Risk factors; World Cancer Research Fund.

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Conflict of interest statement

Conflicts of Interest: The authors declare no conflicts of interest.

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