Noninferiority is (too) common in noninferiority trials

Affiliations

¹ Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. Electronic address: d.soonawala@lumc.nl.
² Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
³ Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
⁴ Department of Social & Preventive Medicine, Institute of Social and Preventive Medicine, University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland.

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Comment

Darius Soonawala et al. J Clin Epidemiol. 2016 Mar.

Free article

. 2016 Mar:71:118-20.

doi: 10.1016/j.jclinepi.2015.11.009. Epub 2015 Dec 1.

¹ Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. Electronic address: d.soonawala@lumc.nl.
² Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
³ Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
⁴ Department of Social & Preventive Medicine, Institute of Social and Preventive Medicine, University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland.

No abstract available

Comment in

Noninferiority is almost certain with lenient noninferiority margins.
Flacco ME, Manzoli L, Ioannidis JP. Flacco ME, et al. J Clin Epidemiol. 2016 Mar;71:118. doi: 10.1016/j.jclinepi.2015.11.010. Epub 2015 Dec 1. J Clin Epidemiol. 2016. PMID: 26607237 No abstract available.

Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor.
Flacco ME, Manzoli L, Boccia S, Capasso L, Aleksovska K, Rosso A, Scaioli G, De Vito C, Siliquini R, Villari P, Ioannidis JP. Flacco ME, et al. J Clin Epidemiol. 2015 Jul;68(7):811-20. doi: 10.1016/j.jclinepi.2014.12.016. Epub 2015 Feb 7. J Clin Epidemiol. 2015. PMID: 25748073 Review.