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. 2015 Nov;28(4):356-65.
doi: 10.1016/j.apnr.2015.01.005. Epub 2015 Feb 26.

Single subject design: Use of time series analyses in a small cohort to understand adherence with a prescribed fluid restriction

Carolyn Miller Reilly  1 , Melinda Higgins  2 , Andrew Smith  3 , Steven D Culler  4 , Sandra B Dunbar  2
Affiliations

Single subject design: Use of time series analyses in a small cohort to understand adherence with a prescribed fluid restriction

Carolyn Miller Reilly et al. Appl Nurs Res. 2015 Nov.

Abstract

Purpose: This paper presents a secondary in-depth analysis of five persons with heart failure randomized to receive an education and behavioral intervention on fluid restriction as part of a larger study.

Methods: Using a single subject analysis design, time series analyses models were constructed for each of the five patients for a period of 180 days to determine correlations between daily measures of patient reported fluid intake, thoracic impedance, and weights, and relationships between patient reported outcomes of symptom burden and health related quality of life over time.

Results: Negative relationships were observed between fluid intake and thoracic impedance, and between impedance and weight, while positive correlations were observed between daily fluid intake and weight.

Conclusions: By constructing time series analyses of daily measures of fluid congestion, trends and patterns of fluid congestion emerged which could be used to guide individualized patient care or future research endeavors. Employment of such a specialized analysis technique allows for the elucidation of clinically relevant findings potentially disguised when only evaluating aggregate outcomes of larger studies.

Keywords: Electric impedance; Fluid therapy; Heart failure; Research design; Self-care.

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Figures

Figure 1
Figure 1
Subject A Time Series Analysis Plot of fluid intake, thoracic impedance, and weight over 180 days.
Figure 2
Figure 2
Subject B Time Series Analysis Plot of fluid intake, thoracic impedance, and weight over 180 days.
Figure 3
Figure 3
Subject C Time Series Analysis Plot of fluid intake, thoracic impedance, and weight over 180 days.
Figure 4
Figure 4
Subject D Time Series Analysis Plot of fluid intake, thoracic impedance, and weight over 180 days.
Figure 5
Figure 5
Subject E Time Series Analysis Plot of fluid intake, thoracic impedance, and weight over 180 days.
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