Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Nov 23;35(4):401-2.
doi: 10.1016/j.devcel.2015.11.009.

Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins

Edward M De Robertis  1 , Diego Ploper  2
Affiliations
Comment

Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins

Edward M De Robertis et al. Dev Cell. .

Abstract

Inhibition of GSK3 by Wnt signaling stabilizes many cellular proteins, but proof that this effect is independent of β-catenin-mediated transcription is lacking. Koch, Acebron, and colleagues (2015) now demonstrate that transcriptionally silent mammalian sperm require Wnt signaling via exosomes to prevent protein degradation during their lengthy travels through the epididymis.

PubMed Disclaimer

Comment on

Publication types