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Review
. 2015 Nov 24;7(11):6080-8.
doi: 10.3390/v7112929.

Recent Advances in BLV Research

Pierre-Yves Barez  1 , Alix de Brogniez  2 , Alexandre Carpentier  3 , Hélène Gazon  4 , Nicolas Gillet  5 , Gerónimo Gutiérrez  6 , Malik Hamaidia  7 , Jean-Rock Jacques  8 , Srikanth Perike  9 , Sathya Neelature Sriramareddy  10 , Nathalie Renotte  11 , Bernard Staumont  12 , Michal Reichert  13 , Karina Trono  14 , Luc Willems  15
Affiliations
Review

Recent Advances in BLV Research

Pierre-Yves Barez et al. Viruses. .

Abstract

Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

Keywords: BLV; HDAC; HTLV-1; Tax; microRNA; vaccine.

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Figures

Figure 1
Figure 1
Schematic structure of (a) the bovine leukemia virus (BLV) genome and (b) the viral particle.
See this image and copyright information in PMC

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