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Comment
. 2016 Jan;26(1):1-3.
doi: 10.1016/j.tcb.2015.11.001. Epub 2015 Nov 21.

Autophagy Mediates Tumor Suppression via Cellular Senescence

Lorenzo Galluzzi  1 , José Manuel Bravo-San Pedro  2 , Guido Kroemer  3
Affiliations
Comment

Autophagy Mediates Tumor Suppression via Cellular Senescence

Lorenzo Galluzzi et al. Trends Cell Biol. 2016 Jan.

Abstract

Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.

Keywords: ATG7; HRAS; LC3; cytoplasmic chromatin fragments; lamin B1; tumor suppression.

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  • Autophagy mediates degradation of nuclear lamina.
    Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL. Dou Z, et al. Nature. 2015 Nov 5;527(7576):105-9. doi: 10.1038/nature15548. Epub 2015 Oct 28. Nature. 2015. PMID: 26524528 Free PMC article.

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