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Review
. 2015 Dec;8(4):561-80.
doi: 10.1016/j.path.2015.08.003. Epub 2015 Oct 21.

Molecular Updates in Prostate Cancer

George J Netto  1
Affiliations
Review

Molecular Updates in Prostate Cancer

George J Netto. Surg Pathol Clin. 2015 Dec.

Abstract

A wide array of molecular markers and genomic signatures, reviewed in this article, may soon be used as adjuncts to currently established screening strategies, prognostic parameters, and early detection markers. Markers of genetic susceptibility to PCA, recurrent epigenetic and genetic alterations, including ETS gene fusions, PTEN alterations, and urine-based early detection marker PCA3, are discussed. Impact of recent genome-wide assessment on our understanding of key pathways of PCA development and progression and their potential clinical implications are highlighted.

Keywords: Carcinogenesis; Genomic classification; PCA3; Prostate cancer.

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