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Comment
. 2015 Dec;17(12):1515-7.
doi: 10.1038/ncb3278.

Rethinking glutamine addiction

Abigail S Krall  1 , Heather R Christofk  1
Affiliations
Comment

Rethinking glutamine addiction

Abigail S Krall et al. Nat Cell Biol. 2015 Dec.

Abstract

Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.

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