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Comment
. 2016 Jan 1;8(1):1-2.
doi: 10.15252/emmm.201505943.

When endothelial cells go rogue

Pei-Yu Chen  1 , Michael Simons  2
Affiliations
Comment

When endothelial cells go rogue

Pei-Yu Chen et al. EMBO Mol Med. .

Abstract

Endothelial‐to‐mesenchymal transition (EndMT) is a poorly understood phenomenon that leads to endothelial cells acquiring a variety of different mesenchymal fates. This results in a number of pathological consequences of considerable clinical significance in diseases ranging from cavernous malformations in the brain to tissue fibrosis, atherosclerosis, and cancer. Importantly, while there appears to be a number of different triggers activating EndMT, the final common pathway driving the transition appears to be the same.

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Figures

Figure 1
Figure 1. Two different signaling pathways leading to EndMT
The loss of either CCM (left) or FGFR1 (right) leads to EndMT via two distinctly different pathways converging on activation of KLF4/Smad‐dependent transcription of the mesenchymal program.
See this image and copyright information in PMC

Comment on

References

    1. Bravi L, Rudini N, Cuttano R, Giampietro C, Maddaluno L, Ferrarini L, Adams RH, Corada M, Boulday G, Tournier‐Lasserve E et al (2015) Sulindac metabolites decrease cerebrovascular malformations in CCM3‐knockout mice. Proc Natl Acad Sci USA 112: 8421–8426 - PMC - PubMed
    1. Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ et al (2012) FGF regulates TGF‐beta signaling and endothelial‐to‐mesenchymal transition via control of let‐7 miRNA expression. Cell Rep 2: 1684–1696 - PMC - PubMed
    1. Chen PY, Qin L, Tellides G, Simons M (2014) Fibroblast growth factor receptor 1 is a key inhibitor of TGFbeta signaling in the endothelium. Sci Signal 7: ra90 - PubMed
    1. Chen P‐Y, Qin L, Baeyens N, Li G, Afolabi T, Budatha M, Tellides G, Schwartz MA, Simons M (2015) Endothelial‐to‐mesenchymal transition drives atherosclerosis progression. J Clin Invest doi:10.1172/JCI82719 - DOI - PMC - PubMed
    1. Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD et al (2014) TGF‐beta signaling mediates endothelial‐to‐mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med 6: 227ra234 - PMC - PubMed

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