Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016 May-Jun;82(3):275-80.
doi: 10.1016/j.bjorl.2015.05.011. Epub 2015 Oct 19.

Partial laryngectomy in glottic cancer: complications and oncological results

Agnaldo José Graciano  1 , Marina Sonagli  2 , Ana Gabriela Clemente da Silva  2 , Carlos Augusto Fischer  3 , Carlos Takahiro Chone  4
Affiliations
Comparative Study

Partial laryngectomy in glottic cancer: complications and oncological results

Agnaldo José Graciano et al. Braz J Otorhinolaryngol. 2016 May-Jun.

Abstract
in English, Portuguese

Introduction: Most patients with laryngeal carcinoma present tumors in the glottis that can be treated by different treatment modalities. Some authors consider open partial laryngectomy as obsolete, while others still deem this as a viable and cost-efficient option.

Objectives: To compare the oncological and functional results of a series of patients undergoing partial laryngectomy vs. external radiotherapy for the treatment of glottic cancer.

Methods: Historical cohort study with a series of glottic carcinoma patients undergoing partial laryngectomy or external radiotherapy during a period of ten years.

Results: Sixty-two patients with glottic carcinoma were included. Group A comprised those submitted to partial laryngectomy (n=30), and Group B, those who underwent radiotherapy (n=32). They were homogeneous in the comparison of mean age, 56.4 vs. 60.4 years (p=0.12) and distribution in pathological stage (p=0.91). With regard to oncological outcome, there were no differences in distant metastasis rates, or second primary tumor between groups (p=1.0), as well as in disease-free time, laryngeal rescue-free time, and overall five-year survival. Severe complication rates were also similar between groups.

Conclusion: Open partial laryngectomy had complication rates and oncological results similar to those of radiotherapy for patients with glottic carcinomas and should still be considered among the main available therapeutic options.

Introdução: A maioria dos pacientes com carcinoma de laringe apresentam tumores na região glótica suscetíveis a diferentes modalidades de tratamento. Alguns autores consideram a laringectomia parcial aberta em desuso enquanto outros ainda a indicam como uma opção viável e custo eficiente.

Objetivos: Comparar os resultados oncológicos e funcionais de uma série de pacientes submetidos à laringectomia parcial versus radioterapia externa para o tratamento do câncer glótico.

Método: Estudo tipo coorte histórica com uma série de pacientes com carcinoma glótico submetidos à laringectomia parcial ou radioterapia externa em período de 10 anos.

Resultados: Foram incluídos 62 pacientes com carcinoma glótico distribuídos em Grupo A: submetido à laringectomia parcial (n = 30) e Grupo B submetido a radioterapia (n = 32) que se mostraram homogêneos na comparação de média de idade de 56,4 vs. 60,4 (p = 0,12) e distribuição em estadios patológicos (p = 0,91). Com relação ao desfecho oncológico, não foram observadas diferenças nas taxas de metástase à distancia, ou segundo primário entre os grupos (p = 1,0) assim como no tempo livre de doença, tempo livre de resgate laríngeo e sobrevida geral em 5 anos. As taxas de complicações severas também foram semelhantes entre os grupos.

Conclusão: A laringectomia parcial aberta apresentou taxas de complicações e resultados oncológicos semelhante àqueles do tratamento radioterápico para pacientes com carcinomas glóticos e ainda deve ser considera entre as principais opções terapêuticas disponíveis.

Keywords: Carcinoma; Laringe; Laringectomia; Laryngectomy; Larynx; Radioterapia; Radiotherapy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Relapse-free time/months.
Figure 2
Figure 2
Larynx rescue-free time.
Figure 3
Figure 3
Overall survival.
See this image and copyright information in PMC

References

    1. INCA; Rio de Janeiro: 2014. Estimativa 2014: Incidência de Câncer no Brasil/Instituto Nacional de Câncer José Alencar Gomes da Silva, Coordenação de Prevenção e Vigilância.http://www.inca.gov.br/estimativa/2014/estimativa-24042014.pdf
    1. Groome P.A., O'Sullivan B., Irish J.C., Rothwell D.M., Math K.S., Bissett R.J., et al. Glottic cancer in Ontario, Canada and the SEER areas of the United States: do different management philosophies produce different outcome profiles? J Clin Epidemiol. 2001;54:301–315. - PubMed
    1. Jemal A., Murray T., Ward E., Samuels A., Tiwari R.C., Ghafoor A., et al. Cancer statistics, 2005. CA Cancer J Clin. 2005;55:10–30. - PubMed
    1. Back G., Sood S. The management of early laryngeal cancer: options for patients and therapists. Curr Opin Otolaryngol Head Neck Surg. 2005;13:85–91. - PubMed
    1. Stewart B.W., Wild C.P., editors. World Cancer Report 2014. World Health Organization; Lyon: 2014. pp. 1488–1524.

Publication types

LinkOut - more resources