Multicenter Study
doi: 10.5588/ijtld.15.0327.
Nosocomial transmission of multidrug-resistant tuberculosis
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- PMID: 26614195
- DOI: 10.5588/ijtld.15.0327
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Multicenter Study
Nosocomial transmission of multidrug-resistant tuberculosis
Int J Tuberc Lung Dis.
2015 Dec.
Abstract
Nosocomial transmission of multidrug-resistant tuberculosis (MDR-TB) was ascertained by 24-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) and spoligotyping at four hospitals in the Republic of Moldova, a high MDR-TB burden country. Overall, 5.1% of patients with pan-susceptible TB at baseline were identified with MDR-TB during in-patient treatment. In 75% of cases, the MDR-TB strain was genetically distinct from the non-MDR-TB strain at baseline, suggesting a high rate of nosocomial transmission of MDR-TB. The highest proportion (40.3%) of follow-up MDR-TB isolates was associated with the M. tuberculosis URAL 163-15 strain.
Comment in
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The impact of mixed infections on the interpretation of molecular epidemiology studies of tuberculosis.Int J Tuberc Lung Dis. 2016 Mar;20(3):423-4. doi: 10.5588/ijtld.15.1024. Int J Tuberc Lung Dis. 2016. PMID: 27046727 Free PMC article. No abstract available.
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In reply.Int J Tuberc Lung Dis. 2016 Mar;20(3):424. doi: 10.5588/ijtld.15.1024-2. Int J Tuberc Lung Dis. 2016. PMID: 27046728 No abstract available.
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