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Comparative Study
. 1977 May;43(5):707-19.
doi: 10.1016/0030-4220(77)90055-x.

Influence of obesity and hypertension on the severity of periodontitis in rats

M I Perlstein, N F Bissada
Comparative Study

Influence of obesity and hypertension on the severity of periodontitis in rats

M I Perlstein et al. Oral Surg Oral Med Oral Pathol. 1977 May.

Abstract

The purpose of this investigation was to evaluate the extent to which obesity and/or hypertension may modify the response of rats' periodontium to chronic gingival irritation. Forty-four normal, spontaneously hypertensive, obese, and obese-hypertensive rats were used. Histopathologic evaluation of the periodontal structure showed both hyperplasia and hypertrophy of the walls of blood vessels supplying the periodontium in the hypertensive and obese-hypertensive animals. The results also indicated that obesity significantly contributed to e severity of periodontal disease. Hypertension alone was not a significant factor. The obese-hypertensive rats showed the most severe periodontal response to local irritation.

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