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Randomized Controlled Trial
. 2016 Apr;62(2):101-6.
doi: 10.1093/tropej/fmv079. Epub 2015 Nov 27.

Effect of Sucrose Analgesia, for Repeated Painful Procedures, on Short-term Neurobehavioral Outcome of Preterm Neonates: A Randomized Controlled Trial

Shreshtha Banga  1 , Vikram Datta  2 , Harmeet Singh Rehan  3 , Bhanu Kiran Bhakhri  4
Affiliations
Randomized Controlled Trial

Effect of Sucrose Analgesia, for Repeated Painful Procedures, on Short-term Neurobehavioral Outcome of Preterm Neonates: A Randomized Controlled Trial

Shreshtha Banga et al. J Trop Pediatr. 2016 Apr.

Abstract

Background: Safety of oral sucrose, commonly used procedural analgesic in neonates, is questioned.

Aim: To evaluate the effect of sucrose analgesia, for repeated painful procedures, on short-term neurobehavioral outcome of preterm neonates.

Methods: Stable preterm neonates were randomized to receive either sucrose or distilled water orally, for every potentially painful procedure during the first 7 days after enrollment. Neurodevelopmental status at 40 weeks postconceptional age (PCA) measured using the domains of Neurobehavioral Assessment of Preterm Infants scale.

Results: A total of 93 newborns were analyzed. The baseline characteristics of the groups were comparable. No statistically significant difference was observed in the assessment at 40 weeks PCA, among the groups. Use of sucrose analgesia, for repeated painful procedures on newborns, does not lead to any significant difference in the short-term neurobehavioral outcome.

Keywords: neurobehavior; procedural pain; sucrose analgesia.

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Figures

Fig. 1.
Fig. 1.
Flow diagram depicting flow of the study from enrollment to analysis.
See this image and copyright information in PMC

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