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. 2016 Jan 4;44(D1):D58-66.
doi: 10.1093/nar/gkv1311. Epub 2015 Nov 28.

Biocuration of functional annotation at the European nucleotide archive

Richard Gibson  1 , Blaise Alako  2 , Clara Amid  2 , Ana Cerdeño-Tárraga  2 , Iain Cleland  2 , Neil Goodgame  2 , Petra Ten Hoopen  2 , Suran Jayathilaka  2 , Simon Kay  2 , Rasko Leinonen  2 , Xin Liu  2 , Swapna Pallreddy  2 , Nima Pakseresht  2 , Jeena Rajan  2 , Marc Rosselló  2 , Nicole Silvester  2 , Dmitriy Smirnov  2 , Ana Luisa Toribio  2 , Daniel Vaughan  2 , Vadim Zalunin  2 , Guy Cochrane  2
Affiliations

Biocuration of functional annotation at the European nucleotide archive

Richard Gibson et al. Nucleic Acids Res. .

Abstract

The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena) is a repository for the submission, maintenance and presentation of nucleotide sequence data and related sample and experimental information. In this article we report on ENA in 2015 regarding general activity, notable published data sets and major achievements. This is followed by a focus on sustainable biocuration of functional annotation, an area which has particularly felt the pressure of sequencing growth. The importance of functional annotation, how it can be submitted and the shifting role of the biocurator in the context of increasing volumes of data are all discussed.

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Figures

Figure 1.
Figure 1.
Example of Feature Table annotation for an HLA-A gene (taken from ENA accession LN873232). See the text for details.
Figure 2.
Figure 2.
Submission workflow for functional annotation submissions under sustainable biocuration. The top level shows the flow through the submitter interface. The bottom level shows those biocurator roles which directly influence functional annotation submissions in ENA. Linking the work of the biocurator with the submitter interface is the autonomous system represented by the middle level.
See this image and copyright information in PMC

References

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