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Review
. 2015;20(6-7):339-54.
doi: 10.3109/1354750X.2015.1101785.

Circulating RNA: looking at the liver through a frosted glass

J M Falcon-Perez  1   2 , F Royo  1
Affiliations
Review

Circulating RNA: looking at the liver through a frosted glass

J M Falcon-Perez et al. Biomarkers. 2015.

Abstract

Context: The evaluation of the liver condition, based on serum enzymatic activity and biopsies, is insufficient. Therefore, it is a priority to find a correlation between circulating RNAs and liver damage.

Methods: Publications were retrieved by the search terms "circulating RNA AND liver".

Results: Although differences exist between studies, a profile of RNAs that repeatedly appeared as indicators of liver damage was identified.

Discussion: We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms.

Conclusion: Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases.

Keywords: Blood; extracellular vesicles; hepatic diseases; miRNA.

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